---
title: >-
  Do Atopic Dermatitis Patient-Reported Outcomes Correlate With Validated
  Investigator Global Assessment? Insights From TARGET-AD Registry.
description: >-
  Explore this publication on real-world evidence: Do Atopic Dermatitis
  Patient-Reported Outcomes Correlate With Validated Investigator Global
  Assessment?…
date: '2023-01-01'
category: Publications
tags:
  - Journal Of Drugs In Dermatology
  - Abstract / Manuscript
  - R&D
  - Care
  - Dermatology
  - Atopic Dermatitis (AD)
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/journal-of-drugs-in-dermatology/do-atopic-dermatitis-patient-reported-outcomes-correlate/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: do-atopic-dermatitis-patient-reported-outcomes-correlate
id: 4A9QEePNTcgzY0c8MdmRes
contentType: article
---

## Challenge

Patient-reported outcomes in AD are increasingly required for drug approval, but the degree to which validated PRO instruments—including POEM and DLQI—correlate with clinician-assessed disease severity (vIGA-AD) in real-world practice had not been established, creating uncertainty about whether PROs can serve as stand-alone endpoints.

## Solution

The TARGET-DERM AD registry was used to assess the correlation between vIGA-AD scores and PRO measures (POEM, DLQI/CDLQI) across the full spectrum of AD severity, using regression analyses to characterize the strength and directionality of the vIGA-AD/PRO relationship.

## Impact

Demonstrating strong correlation between clinician-assessed vIGA-AD and patient-reported outcomes validates PRO instruments as meaningful reflections of clinical reality, supporting their use as primary or co-primary endpoints in AD registration trials and strengthening the regulatory acceptability of PRO-based label claims.

### [Breda Munoz](/people/breda-munoz/)

![Breda Munoz, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/3H1T2mfvSNFj6w9tulnreq/a74ae05fe53e400f176d4e9c617b8fb8/breda-munoz.jpg)

### [Keith D. Knapp](/people/keith-knapp/)

### [Rachel W. Faller](/people/rachel-faller/)

### [Julie M. Crawford](/people/julie-crawford/)