---
title: >-
  Effectiveness of Remdesivir Treatment Protocols Among Patients Hospitalized
  with COVID-19: A Target Trial Emulation.
description: >-
  Explore this publication on real-world evidence: Effectiveness of Remdesivir
  Treatment Protocols Among Patients Hospitalized with COVID-19: A Target Trial…
date: '2023-01-01'
category: Publications
tags:
  - Epidemiology
  - Abstract / Manuscript
  - R&D
  - Care
  - Methods/Pharmacoepi
  - COVID-19
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/epidemiology/effectiveness-of-remdesivir-treatment-protocols-among/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: effectiveness-of-remdesivir-treatment-protocols-among
id: 3zDv9q0smxvkkZUeMvxzjg
contentType: article
---

## Challenge

Remdesivir became a standard of care for hospitalized COVID-19 patients, but its real-world effectiveness across different initiation timing protocols—accounting for time-varying treatment decisions—had not been estimated using rigorous causal methods.

## Solution

Target RWE researchers applied the clone-censor-weight design to a large hospital chargemaster dataset to compare remdesivir treatment protocols, accounting for time-varying patient characteristics that determine both treatment timing and outcomes.

## Impact

Demonstrating that early remdesivir initiation significantly reduces in-hospital mortality when analyzed with causal methods validates clone-censor-weighting as Target RWE's approach for complex treatment timing questions, supporting Gilead's post-authorization effectiveness evidence strategy.

### [Julie M. Crawford](/people/julie-crawford/)

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)