---
title: >-
  Factors Predicting Loss of Remission in Crohn’s Disease Patients in Endoscopic
  Remission in the Real World Results From TARGET-IBD.
description: >-
  Explore this publication on real-world evidence: Factors Predicting Loss of
  Remission in Crohn’s Disease Patients in Endoscopic Remission in the Real
  World…
date: '2024-01-01'
category: Publications
tags:
  - Journal Of Clinical Gastroenterology
  - Abstract / Manuscript
  - Approval / Commercialization
  - Care
  - Gastroenterology
  - IBD
  - Pharma Partner
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/journal-of-clinical-gastroenterology/factors-predicting-loss-of-remission-in-crohn-s-disease/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: factors-predicting-loss-of-remission-in-crohn-s-disease
id: 5gNr5p3roDcChjAemRkMaa
contentType: article
---

## Challenge

Among CD patients in endoscopic remission, a substantial proportion experience loss of remission over time, but the real-world predictors of LOR—particularly the role of residual histologic inflammation despite endoscopic quiescence—had not been characterized in a large prospective US cohort.

## Solution

The TARGET-IBD registry was analyzed to identify predictors of LOR among CD patients with steroid-free endoscopic remission, with histologic inflammation and biologic use at index colonoscopy evaluated as independent predictors using multivariable Cox proportional hazards regression.

## Impact

Establishing that histologic inflammation despite endoscopic remission nearly doubles LOR risk in real-world CD patients provides evidence for deep remission—encompassing histologic healing—as the optimal treatment target, directly informing treat-to-target strategies for next-generation CD therapies.

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)

### [Julie M. Crawford](/people/julie-crawford/)