---
title: >-
  High Concordance Between Nonalcoholic Fatty Liver Disease and Metabolic
  Dysfunction-Associated Steatotic Liver Disease in the TARGET-NASH Real-World
  Cohort.
description: >-
  Explore this publication on real-world evidence: High Concordance Between
  Nonalcoholic Fatty Liver Disease and Metabolic Dysfunction-Associated
  Steatotic…
date: '2024-01-01'
category: Publications
tags:
  - American Journal of Gastroenterology
  - Abstract / Manuscript
  - Approval / Commercialization
  - Care
  - Hepatology
  - MASH/MASLD
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/american-journal-gastroenterology/high-concordance-between-nonalcoholic-fatty-liver-disease/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: high-concordance-between-nonalcoholic-fatty-liver-disease
id: 7JdOQ8W7IZwA1py6VZZ9pr
contentType: article
---

## Challenge

The 2023 global nomenclature shift from NAFLD/NASH to MASLD/MASH created immediate uncertainty for sponsors and investigators about whether patients enrolled under prior criteria could be re-classified, potentially invalidating years of longitudinal follow-up data.

## Solution

The TARGET-NASH cohort was interrogated to assess the degree of overlap between NAFLD and MASLD case definitions across a large, multi-site US population, providing the first real-world concordance estimate at population scale.

## Impact

Demonstrating very high concordance between NAFLD and MASLD classifications validates the continued use of the TARGET-NASH longitudinal dataset under the new nomenclature, directly protecting the investment in existing RWE infrastructure and supporting uninterrupted evidence generation for drug development.

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)