---
title: >-
  High PrEP uptake and objective longitudinal adherence among HIV-exposed women
  with personal or partner plans for pregnancy in rural Uganda: A cohort study.
description: >-
  Explore this publication on real-world evidence: High PrEP uptake and
  objective longitudinal adherence among HIV-exposed women with personal or
  partner plans…
date: '2023-01-01'
category: Publications
tags:
  - Plos Medicine
  - Abstract / Manuscript
  - R&D
  - Care
  - Methods/Pharmacoepi
  - HIV
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/plos-medicine/high-prep-uptake-and-objective-longitudinal-adherence-among/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: high-prep-uptake-and-objective-longitudinal-adherence-among
id: yOcolCMMUIVUiHiIEH4vK
contentType: article
---

## Challenge

High PrEP uptake had been observed in controlled settings, but whether women with personal or partner HIV risk would achieve high objective adherence to daily oral TDF/FTC PrEP in real-world periconception settings remained unknown.

## Solution

Target RWE's HIV team analyzed longitudinal PrEP uptake and objective adherence data from HIV-exposed South African women with personal or partner HIV risk planning for pregnancy.

## Impact

Demonstrating high PrEP uptake and objective adherence among motivated periconception women provides evidence that real-world PrEP effectiveness is achievable, informing HIV prevention program scaling strategies.