---
title: >-
  Impact of Pruritus on Quality of Life and Current Treatment Patterns in
  Patients with Primary Biliary Cholangitis.
description: >-
  Explore this publication on real-world evidence: Impact of Pruritus on Quality
  of Life and Current Treatment Patterns in Patients with Primary Biliary…
date: '2022-01-01'
category: Publications
tags:
  - Digestive Diseases And Sciences
  - Abstract / Manuscript
  - Approval / Commercialization
  - Care
  - Hepatology
  - PBC
  - Pharma Partner
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/digestive-diseases-and-sciences/impact-of-pruritus-on-quality-of-life-and-current-treatment/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: impact-of-pruritus-on-quality-of-life-and-current-treatment
id: 3Pf6Ra2MHYfDsyAdBNSJIJ
contentType: article
---

## Challenge

Despite pruritus being the most burdensome symptom in PBC, real-world data quantifying its impact on health-related quality of life across multiple domains—and characterizing the treatment gap—were absent, limiting the ability of sponsors and regulators to establish the clinical meaningfulness of anti-pruritic endpoints.

## Solution

The TARGET-PBC longitudinal cohort was used to analyze PBC-40, 5D-Itch, and PROMIS Fatigue survey data across 211 patients stratified by itch severity, characterizing multi-domain quality of life impairment and describing current treatment patterns in real-world US practice.

## Impact

Establishing that clinically significant pruritus in PBC is associated with pervasive multi-domain quality of life impairment and is systematically undertreated provides the clinical meaningfulness anchor for anti-pruritic endpoints and directly supports regulatory submissions for therapies targeting PBC itch.

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)