---
title: >-
  Methodology and initial results from a real-world observational cohort of
  patients with inflammatory bowel disease: TARGET-IBD.
description: >-
  Explore this publication on real-world evidence: Methodology and initial
  results from a real-world observational cohort of patients with inflammatory
  bowel…
date: '2021-01-01'
category: Publications
tags:
  - Crohn S Colitis 360
  - Abstract / Manuscript
  - R&D
  - Gastroenterology
  - IBD
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/crohn-s-colitis-360/methodology-and-initial-results-from-a-real-world/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: methodology-and-initial-results-from-a-real-world
id: 4Mi6Uhz15nAVgEUqBtOoaB
contentType: article
---

## Challenge

Advanced IBD drug development required a large-scale, prospective, longitudinal real-world registry with the depth of clinical, endoscopic, biomarker, and patient-reported data needed to generate comparative effectiveness evidence for the expanding landscape of biologic and small molecule therapies.

## Solution

The TARGET-IBD registry was designed and launched as a prospective longitudinal observational cohort of adult and pediatric IBD patients at 34 academic and community US sites, with centrally abstracted electronic health records, quarterly PROs, and an annual biospecimen repository.

## Impact

Establishing the TARGET-IBD registry created the foundational real-world infrastructure for all subsequent IBD treatment pattern, safety, effectiveness, and natural history studies, directly enabling partnerships with AbbVie, Bristol Myers Squibb, Merck, and other sponsors across the expanding IBD therapy landscape.

### [Laura Dalfonso](/people/laura-dalfonso/)

![Laura Dalfonso, MBA — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/1EHQvEOTdVN9mIxegyhbip/0abef5a018b51d2ebbf1ea54555fe26b/laura-dalfonso.jpg)

### [Julie M. Crawford](/people/julie-crawford/)