---
title: >-
  Prevalence and burden of atopic dermatitis involving the head, neck, face, and
  hand: A cross sectional study from the TARGET-DERM AD cohort.
description: >-
  Explore this publication on real-world evidence: Prevalence and burden of
  atopic dermatitis involving the head, neck, face, and hand: A cross sectional
  study…
date: '2023-01-01'
category: Publications
tags:
  - Journal Of The American Academy Of Dermatology
  - Abstract / Manuscript
  - R&D
  - Care
  - Dermatology
  - Atopic Dermatitis (AD)
  - Health System Partner
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source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: prevalence-and-burden-of-atopic-dermatitis-involving-the
id: cw8RtBd112NzrMGROydhV
contentType: article
---

## Challenge

AD involving the head, neck, face, and hands—so-called difficult-to-treat sites—is associated with high visibility and psychosocial impact, but the real-world prevalence and HRQoL burden of AD at these anatomical locations had not been systematically quantified in a large US population spanning all age groups.

## Solution

The TARGET-DERM AD cohort was used to estimate the prevalence of head, neck, face, and hand involvement among patients with moderate-to-severe AD and quantify the incremental HRQoL burden associated with involvement at these sites, using POEM and DLQI/CDLQI outcomes.

## Impact

Establishing that 85% of moderate-to-severe AD patients have difficult-to-treat site involvement, which is independently associated with significantly worse QoL, provides the epidemiological and clinical meaningfulness evidence for trials and label claims specifically targeting AD at these high-impact anatomical locations.

### [Breda Munoz](/people/breda-munoz/)

![Breda Munoz, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/3H1T2mfvSNFj6w9tulnreq/a74ae05fe53e400f176d4e9c617b8fb8/breda-munoz.jpg)

### [Rachel W. Faller](/people/rachel-faller/)

### [Julie M. Crawford](/people/julie-crawford/)