---
title: >-
  Real-world evidence on the benefits of optimal itch relief and skin clearance
  in atopic dermatitis management: a study from the TARGET-DERM AD registry.
description: >-
  Explore this publication on real-world evidence: Real-world evidence on the
  benefits of optimal itch relief and skin clearance in atopic dermatitis…
date: '2024-01-01'
category: Publications
tags:
  - Journal Of Dermatological Treatment
  - Abstract / Manuscript
  - Approval / Commercialization
  - Care
  - Dermatology
  - Atopic Dermatitis (AD)
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/journal-of-dermatological-treatment/real-world-evidence-on-the-benefits-of-optimal-itch-relief/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: real-world-evidence-on-the-benefits-of-optimal-itch-relief
id: 5EFX6UVMzOD3xFkWNMbLkS
contentType: article
---

## Challenge

Treat-to-target frameworks in AD emphasize achieving both itch relief and skin clearance as optimal endpoints, but real-world evidence on whether achieving these combined targets independently and synergistically drives patient-reported outcomes had not been established, limiting the evidence base for these ambitious treatment goals.

## Solution

The TARGET-DERM AD registry was used to conduct a cross-sectional analysis evaluating the independent and combined effects of optimal itch (WI-NRS 0/1) and skin clearance (vIGA-AD 0/1) on POEM, DLQI, NRS-Sleep, and NRS-Pain outcomes, using logistic regression to quantify their relative contributions.

## Impact

Demonstrating that achieving both optimal itch and skin clearance produces synergistic PRO improvements—greater than either alone—provides the real-world evidentiary foundation for ambitious treat-to-target endpoints in AD trials and supports label claims for therapies capable of achieving both simultaneously.