---
title: >-
  Unmet Needs of Effective Advanced Systemic Therapies in Moderate-to-Severe
  Atopic Dermatitis Patients in the TARGET-DERM AD Registry.
description: >-
  Explore this publication on real-world evidence: Unmet Needs of Effective
  Advanced Systemic Therapies in Moderate-to-Severe Atopic Dermatitis Patients
  in the…
date: '2025-01-01'
category: Publications
tags:
  - Dermatitis
  - Abstract / Manuscript
  - R&D
  - Care
  - Dermatology
  - Atopic Dermatitis (AD)
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/dermatitis/unmet-needs-of-effective-advanced-systemic-therapies-in/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: unmet-needs-of-effective-advanced-systemic-therapies-in
id: dmdhw42NR1gulVUCbM3aK
contentType: article
---

## Challenge

A substantial proportion of patients with moderate-to-severe AD are eligible for but never receive advanced systemic therapies, yet the real-world scale of this treatment gap—and the longitudinal outcomes of those who do and do not receive AST—had not been characterized in a large North American registry spanning both adolescents and adults.

## Solution

The TARGET-DERM AD registry was used to stratify patients into four subgroups (AST-naïve, AST-retrospective, AST-prospective, and AST-failed) and characterize demographics, clinical outcomes, and longitudinal response trajectories within each, providing a comprehensive real-world picture of the advanced therapy landscape in moderate-to-severe AD.

## Impact

Demonstrating that a third of eligible patients remain AST-naïve and that substantial proportions of AST-treated patients fail to achieve adequate control establishes the unmet need evidence base for new advanced therapies and supports regulatory and payer arguments for next-generation AD treatments.

### [Keith D. Knapp](/people/keith-knapp/)

### [Breda Munoz](/people/breda-munoz/)

![Breda Munoz, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/3H1T2mfvSNFj6w9tulnreq/a74ae05fe53e400f176d4e9c617b8fb8/breda-munoz.jpg)

### [Julie M. Crawford](/people/julie-crawford/)