---
title: >-
  Weight Loss and Weight Regain in Usual Clinical Practice: Results from the
  TARGET-NASH Observational Cohort.
description: >-
  Explore this publication on real-world evidence: Weight Loss and Weight Regain
  in Usual Clinical Practice: Results from the TARGET-NASH Observational
  Cohort..
date: '2021-01-01'
category: Publications
tags:
  - Clinical Gastroenterology & Hepatology
  - Abstract / Manuscript
  - R&D
  - Care
  - Hepatology
  - MASH/MASLD
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/cgh-journal/weight-loss-and-weight-regain-in-usual-clinical-practice/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: weight-loss-and-weight-regain-in-usual-clinical-practice
id: 45C5lCLuu5QkhMsf5ZichF
contentType: article
---

## Challenge

Weight loss is a primary treatment goal in NAFLD, but real-world data on whether patients achieve and sustain clinically meaningful weight loss in usual care—and the predictors of weight regain—were lacking, leaving a gap between clinical trial benchmarks and realistic treatment expectations.

## Solution

The TARGET-NASH observational cohort was used to track weight loss and regain trajectories over time in patients receiving standard care, characterizing the real-world effectiveness of lifestyle intervention and providing empirical benchmarks for trial comparator arms.

## Impact

Documenting that weight regain is common in real-world NAFLD care sets realistic expectations for comparator arm behavior in trials, supports the design of weight-loss-sensitive endpoints, and demonstrates the unmet need for pharmacological intervention beyond lifestyle modification.

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)

### [Breda Munoz](/people/breda-munoz/)

![Breda Munoz, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/3H1T2mfvSNFj6w9tulnreq/a74ae05fe53e400f176d4e9c617b8fb8/breda-munoz.jpg)