---
title: >-
  Clinical Profile of Nonalcoholic Fatty Liver Disease in Adults with Type 2
  Diabetes Mellitus.
description: >-
  Explore this publication on real-world evidence: Clinical Profile of
  Nonalcoholic Fatty Liver Disease in Adults with Type 2 Diabetes Mellitus..
date: '2020-01-01'
category: Publications
tags:
  - ADA
  - Oral Presentation
  - R&D
  - Care
  - Hepatology
  - MASH/MASLD
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/ada/clinical-profile-of-nonalcoholic-fatty-liver-disease-in/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: clinical-profile-of-nonalcoholic-fatty-liver-disease-in
id: DDctGXGiPkY3yph5iRtGu
contentType: article
---

## Challenge

Adults with T2D represent a large and clinically important NAFLD subgroup, but the real-world clinical profile—including disease severity, comorbidities, and treatment patterns—of adults with NAFLD and concurrent T2D had not been systematically characterized at scale.

## Solution

The TARGET-NASH cohort was used to compare clinical characteristics, disease severity distribution, and medication use between NAFLD patients with and without T2D, characterizing the T2D-NAFLD co-morbidity profile in a large real-world US population.

## Impact

Characterizing that NAFLD patients with T2D have higher fibrosis burden and more advanced disease at enrollment provides the evidence base for T2D-based enrichment in NAFLD trials and supports the regulatory rationale for subgroup analyses in metabolic drug development for MASH.

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)