---
title: >-
  Non-alcoholic Steatohepatitis Disease Progression in Participants from the
  United States TARGET-NASH Real World Longitudinal Observational Study.
description: >-
  Explore this publication on real-world evidence: Non-alcoholic Steatohepatitis
  Disease Progression in Participants from the United States TARGET-NASH Real…
date: '2023-01-01'
category: Publications
tags:
  - EASL Congress
  - Oral Presentation
  - Approval / Commercialization
  - Care
  - Hepatology
  - MASH/MASLD
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/easl-congress/non-alcoholic-steatohepatitis-disease-progression-in/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: non-alcoholic-steatohepatitis-disease-progression-in
id: 2pslQpPycfM8WjoUoesgWL
contentType: article
---

## Challenge

Real-world natural history data on NASH disease progression rates—from non-cirrhotic NASH through compensated and decompensated cirrhosis—were needed to support economic modeling, trial powering, and health technology assessment for NASH drug development programs.

## Solution

The TARGET-NASH longitudinal cohort was analyzed to describe MASH disease progression incidence, mortality rates, and time-to-event estimates across severity subgroups, providing prospective real-world natural history data from a large, multi-site US population.

## Impact

Providing prospective disease progression benchmarks from a large US cohort directly supports health economic models used in payer negotiations, informs sample size calculations for outcome trials, and establishes the natural history context required for regulatory submissions.

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)

### [Derek Gazis](/people/derek-gazis/)

![Derek Gazis, MS — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/1e4BaL8aZ7BBWMVV2cF6ev/425b52e4014543560f321fe4edd37631/derek-gazis.jpg)

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)