---
title: >-
  Patient reported burden is associated with clinician-reported severity in
  alopecia areata: Real world insights from TARGET-DERM AA.
description: >-
  Explore this publication on real-world evidence: Patient reported burden is
  associated with clinician-reported severity in alopecia areata: Real world…
date: '2024-01-01'
category: Publications
tags:
  - AAD Annual Meeting
  - Oral Presentation
  - Approval / Commercialization
  - Care
  - Dermatology
  - Alopecia Areata (AA)
  - Pharma Partner
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/aad-annual-meeting/patient-reported-burden-is-associated-with-clinician/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: patient-reported-burden-is-associated-with-clinician
id: 6M5SovFG7tfQ7Qs8W2tX1M
contentType: article
---

## Challenge

AA-specific PRO instruments had been developed, but whether patient-reported disease burden—as measured by AAPPO and PROMIS anxiety/depression—correlates meaningfully with clinician-assessed severity (CGI-AA, SALT) in real-world US/Canadian practice had not been established, creating uncertainty about PRO validity for regulatory purposes.

## Solution

The TARGET-DERM AA registry was used to assess Spearman correlations and regression-based associations between clinician-reported AA severity measures and patient-reported AAPPO and PROMIS outcomes at enrollment, characterizing the degree of agreement between the clinician and patient perspectives.

## Impact

Establishing that patient-reported AA burden correlates significantly with clinician-reported severity provides the convergent validity evidence required for regulatory acceptance of AAPPO as a primary or co-primary endpoint in AA trials, directly supporting the use of PROs in JAK inhibitor label submissions.

### [Breda Munoz](/people/breda-munoz/)

![Breda Munoz, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/3H1T2mfvSNFj6w9tulnreq/a74ae05fe53e400f176d4e9c617b8fb8/breda-munoz.jpg)

### [Keith D. Knapp](/people/keith-knapp/)

### [Julie M. Crawford](/people/julie-crawford/)