---
title: >-
  Use of glucagon-like peptide 1 receptor agonists in patients with MASLD in a
  real-world setting is associated with slower disease progression and lower
  all-cause mortality.
description: >-
  Explore this publication on real-world evidence: Use of glucagon-like peptide
  1 receptor agonists in patients with MASLD in a real-world setting is
  associated…
date: '2024-01-01'
category: Publications
tags:
  - AASLD The Liver Meeting
  - Oral Presentation
  - Approval / Commercialization
  - Care
  - Hepatology
  - MASH/MASLD
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/aasld-liver-meeting/use-of-glucagon-like-peptide-1-receptor-agonists-in/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: use-of-glucagon-like-peptide-1-receptor-agonists-in
id: 214eKUh1deFuGHn7TvKu0S
contentType: article
---

## Challenge

GLP-1 receptor agonists had shown promising signals in MASH but real-world data on their actual use patterns, tolerability, and association with outcomes in the heterogeneous MASLD population receiving usual care—including those with cirrhosis—were essentially absent.

## Solution

The TARGET-NASH cohort was used to characterize GLP-1 RA use prevalence, duration, patient demographics, reasons for discontinuation, and association with all-cause mortality across MASLD disease phenotypes in a cross-sectional analysis spanning thousands of real-world patients.

## Impact

Providing the first large-scale real-world characterization of GLP-1 RA use in MASLD establishes real-world effectiveness context for ongoing GLP-1 clinical programs and informs the design of comparative effectiveness studies assessing GLP-1 RAs as MASLD-modifying therapies.

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)

### [Breda Munoz](/people/breda-munoz/)

![Breda Munoz, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/3H1T2mfvSNFj6w9tulnreq/a74ae05fe53e400f176d4e9c617b8fb8/breda-munoz.jpg)