---
title: >-
  A comparison of stable vs progressive hidradenitis suppurativa: insights from
  TARGET-DERM HS.
description: >-
  Explore this publication on real-world evidence: A comparison of stable vs
  progressive hidradenitis suppurativa: insights from TARGET-DERM HS..
date: '2026-01-01'
category: Publications
tags:
  - Poster Presentation
  - R&D
  - Care
  - Dermatology
  - Hidradenitis Suppurativa (HS)
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/poster-presentation/a-comparison-of-stable-vs-progressive-hidradenitis/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: a-comparison-of-stable-vs-progressive-hidradenitis
id: 3y275zyWTR4URKwcUBYlX8
contentType: article
---

## Challenge

The clinical trajectory of HS in real-world practice—specifically what distinguishes patients with stable disease from those who progress—had not been characterized using a large, prospective multi-site US/Canadian registry, limiting the ability of clinicians and sponsors to identify at-risk patients early.

## Solution

The TARGET-DERM HS registry was analyzed to compare baseline and longitudinal characteristics between stable and progressive HS patients, characterizing the demographic, clinical, and disease-severity features associated with disease progression in usual care.

## Impact

Identifying real-world predictors of HS progression provides drug developers with evidence-based enrichment criteria for clinical trials targeting progressive disease, and gives clinicians actionable signals for earlier escalation of therapy in patients most likely to worsen.