---
title: >-
  A prospective assessment of disease progression impact on patient-reported
  outcomes in metabolic dysfunction-associated steatotic liver disease.
description: >-
  Explore this publication on real-world evidence: A prospective assessment of
  disease progression impact on patient-reported outcomes in metabolic…
date: '2024-01-01'
category: Publications
tags:
  - EASL Congress
  - Poster Presentation
  - R&D
  - Care
  - Hepatology
  - MASH/MASLD
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/easl-congress/a-prospective-assessment-of-disease-progression-impact-on/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: a-prospective-assessment-of-disease-progression-impact-on
id: 4Wce0IG4S1NZGuDY7bdUJx
contentType: article
---

## Challenge

While disease progression in MASH is associated with worsening clinical outcomes, its impact on patient-reported quality of life—across multiple symptom and functional domains using a validated, disease-specific instrument—had not been characterized prospectively in a real-world US cohort.

## Solution

A cross-sectional analysis of NASH-CHECK survey data from TARGET-NASH patients across MASL, MASH, and cirrhosis subgroups was conducted, using regression models to isolate the effect of disease severity on each PRO domain while controlling for demographic and metabolic covariates.

## Impact

Demonstrating significant PRO deterioration across 7 of 9 NASH-CHECK domains with advancing liver disease severity provides clinical meaningfulness anchor data for MASH endpoint design and supports regulatory arguments that disease modification translates into patient-relevant benefit.

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)