---
title: >-
  A prospective assessment of the impact of decompensation of cirrhosis on
  patient-reported outcomes in metabolic dysfunction-associated steatotic liver
  disease.
description: >-
  Explore this publication on real-world evidence: A prospective assessment of
  the impact of decompensation of cirrhosis on patient-reported outcomes in…
date: '2024-01-01'
category: Publications
tags:
  - AASLD The Liver Meeting
  - Poster Presentation
  - R&D
  - Care
  - Hepatology
  - MASH/MASLD
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/aasld-liver-meeting/a-prospective-assessment-of-the-impact-of-decompensation-of/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: a-prospective-assessment-of-the-impact-of-decompensation-of
id: 4TsA514jgbeyFgZwMUHEZp
contentType: article
---

## Challenge

While decompensation is recognized as a critical clinical event in MASH cirrhosis, the specific incremental impact of decompensation on patient-reported quality of life—assessed with a disease-specific PROM—had not been quantified, leaving a gap in the clinical meaningfulness evidence for decompensation-based endpoints.

## Solution

A cross-sectional analysis of NASH-CHECK data from TARGET-NASH patients with compensated vs. decompensated MASH cirrhosis was conducted, using regression models controlling for key covariates to isolate the effect of decompensation on PROM domain scores.

## Impact

Demonstrating that decompensation significantly worsens patient-reported outcomes across all NASH-CHECK domains provides the clinical meaningfulness evidence needed to justify decompensation prevention as a patient-relevant endpoint in MASH trials, supporting regulatory strategies built around liver-related outcomes.

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)