---
title: >-
  Analysis of discrimination and calibration of two cardiovascular risk scores
  in patients with non-alcoholic steatohepatitis shows a need for improved
  accuracy of these models.
description: >-
  Explore this publication on real-world evidence: Analysis of discrimination
  and calibration of two cardiovascular risk scores in patients with
  non-alcoholic…
date: '2023-01-01'
category: Publications
tags:
  - Aha Conference
  - Poster Presentation
  - R&D
  - Care
  - Methods/Pharmacoepi
  - Cardiovascular
  - Pharma Partner
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/aha-conference/analysis-of-discrimination-and-calibration-of-two/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: analysis-of-discrimination-and-calibration-of-two
id: 7t2kHhmaErHEjB73Kf8nmK
contentType: article
---

## Challenge

Cardiovascular risk assessment tools like the Framingham Risk Score and Pooled Cohort Equations were developed in general populations and may not accurately predict CV events in NAFLD/NASH patients, who have distinct metabolic risk profiles.

## Solution

Target RWE and Madrigal Pharmaceuticals researchers analyzed TARGET-NASH data to evaluate the discrimination and calibration of Framingham and PCE risk equations in NAFLD/NASH patients, finding poor predictive accuracy and systematic overestimation.

## Impact

Establishing that standard CV risk tools perform poorly in NAFLD/NASH patients creates the evidence foundation for developing NASH-specific cardiovascular risk models, directly supporting Madrigal's commercial strategy for resmetirom.

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)