---
title: >-
  Biologic-naïve Patients with Crohn’s Disease are More Likely to Achieve
  Mucosal Healing than Biologic-experienced Patients: TARGET-IBD Real World
  Cohort.
description: >-
  Explore this publication on real-world evidence: Biologic-naïve Patients with
  Crohn’s Disease are More Likely to Achieve Mucosal Healing than…
date: '2021-01-01'
category: Publications
tags:
  - DDW
  - Poster Presentation
  - Approval / Commercialization
  - Care
  - Gastroenterology
  - IBD
  - Pharma Partner
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/ddw/biologic-na-ve-patients-with-crohn-s-disease-are-more/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: biologic-na-ve-patients-with-crohn-s-disease-are-more
id: 1cEgFFl4lgBaBK2IdekowE
contentType: article
---

## Challenge

The higher rates of mucosal healing observed in biologic-naïve CD patients in clinical trials had not been validated in real-world practice, where patients are more heterogeneous and biologic sequencing varies. The degree to which prior biologic exposure affects mucosal healing rates in routine care was unknown.

## Solution

The TARGET-IBD registry was used to compare mucosal healing rates between biologic-naïve and biologic-experienced CD patients initiating biologic therapy, with logistic regression identifying baseline factors associated with achieving mucosal healing on follow-up colonoscopy.

## Impact

Confirming in real-world practice that biologic-naïve CD patients are significantly more likely to achieve mucosal healing than biologic-experienced patients validates the clinical trial finding and reinforces the case for early biologic use in CD before therapeutic failure, supporting prescriber education and payer arguments for timely advanced therapy initiation.

### [Julie M. Crawford](/people/julie-crawford/)