---
title: >-
  Characteristics of adult MASH patients and factors associated with
  MASH-relevant clinical endpoints in a real-world US cohort.
description: >-
  Explore this publication on real-world evidence: Characteristics of adult MASH
  patients and factors associated with MASH-relevant clinical endpoints in a…
date: '2024-01-01'
category: Publications
tags:
  - AASLD The Liver Meeting
  - Poster Presentation
  - Approval / Commercialization
  - Care
  - Hepatology
  - MASH/MASLD
  - Pharma Partner
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/aasld-liver-meeting/characteristics-of-adult-mash-patients-and-factors/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: characteristics-of-adult-mash-patients-and-factors
id: 7LEvhznMweLwiNNSCmuopV
contentType: article
---

## Challenge

Beyond understanding population-level disease progression, sponsors and investigators needed to identify which specific patient characteristics—demographic, clinical, geographic, and treatment-related—predict progression to clinically meaningful composite endpoints across MASH severity strata.

## Solution

A companion to the disease progression poster, this analysis used Fine-Gray multivariable hazard models on the same TARGET-NASH population to identify predictors of MASH-relevant composite endpoints within each disease severity subgroup, providing actionable enrichment criteria.

## Impact

Identifying that academic site care, high FIB-4, T2D, and CYP3A inhibitor use predict composite endpoints across disease severity strata provides sponsors with evidence-based criteria for stratifying enrollment in MASH outcome trials and designing risk-adaptive study designs.

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)