---
title: >-
  Clinical Profile of Adults with Nonalcoholic Steatohepatitis (NASH) with and
  without Type 2 Diabetes Mellitus (T2DM).
description: >-
  Explore this publication on real-world evidence: Clinical Profile of Adults
  with Nonalcoholic Steatohepatitis (NASH) with and without Type 2 Diabetes
  Mellitus…
date: '2018-01-01'
category: Publications
tags:
  - ADA
  - Poster Presentation
  - R&D
  - Care
  - Hepatology
  - MASH/MASLD
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/ada/clinical-profile-of-adults-with-nonalcoholic/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: clinical-profile-of-adults-with-nonalcoholic
id: 6jTmZ2YaSJuK45YjWArSBd
contentType: article
---

## Challenge

T2D is highly prevalent in NASH but the specific clinical profile differences between NASH patients with and without T2D—including disease severity, comorbidities, and laboratory parameters—had not been characterized in a large real-world US population, limiting the precision of T2D-based trial enrichment.

## Solution

The TARGET-NASH cohort was used to compare clinical characteristics, disease severity markers, and metabolic profiles between adults with NASH and T2D versus NASH without T2D, providing a detailed real-world characterization of this high-risk subgroup.

## Impact

Characterizing that T2D-associated NASH patients have significantly higher fibrosis burden and more metabolic comorbidities at enrollment provides the evidence base for designing T2D-enriched NASH trials and supports the regulatory argument for T2D subgroup analyses in metabolic MASH programs.