---
title: >-
  Histological Inflammation Predicts Loss of Remission Among Crohn’s Patients
  with Endoscopic Remission: A US Cohort Analysis.
description: >-
  Explore this publication on real-world evidence: Histological Inflammation
  Predicts Loss of Remission Among Crohn’s Patients with Endoscopic Remission: A
  US…
date: '2021-01-01'
category: Publications
tags:
  - UEG Week
  - Poster Presentation
  - R&D
  - Care
  - Gastroenterology
  - IBD
  - Pharma Partner
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/ueg-week/histological-inflammation-predicts-loss-of-remission-among/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: histological-inflammation-predicts-loss-of-remission-among
id: 38PpMGxKyBS4umjjwwNVrU
contentType: article
---

## Challenge

This is the companion Crohn's disease analysis to the UC LOR study (Row 15 / Row 4 manuscript). Earlier UEGW 2021 poster presentation establishing that histologic inflammation in CD endoscopic remission doubles loss of remission risk.

## Solution

The TARGET-IBD registry was used to analyze predictors of LOR among CD patients in steroid-free endoscopic remission, with histologic inflammation and ileal disease identified as independent predictors using logistic regression, funded by Bristol Myers Squibb.

## Impact

First major conference presentation of the CD histologic LOR findings establishes the evidence foundation for histologic remission as a treat-to-target endpoint in CD, supporting prescriber adoption of deeper remission goals and informing BMS's regulatory and commercial strategy for CD therapies.

### [Julie M. Crawford](/people/julie-crawford/)