---
title: >-
  Inflammation on Index Biopsy Predicts Loss of Remission Among Ulcerative
  Colitis Patients with Endoscopic Remission: a US Cohort Analysis.
description: >-
  Explore this publication on real-world evidence: Inflammation on Index Biopsy
  Predicts Loss of Remission Among Ulcerative Colitis Patients with Endoscopic…
date: '2022-01-01'
category: Publications
tags:
  - DDW
  - Poster Presentation
  - R&D
  - Care
  - Gastroenterology
  - GI - Other
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/ddw/inflammation-on-index-biopsy-predicts-loss-of-remission/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: inflammation-on-index-biopsy-predicts-loss-of-remission
id: 4NollqV96zVTGOeCaiMejb
contentType: article
---

## Challenge

Histologic inflammation persists in a significant proportion of UC patients who achieve endoscopic remission, but the real-world impact of residual histologic activity on subsequent loss of remission had not been quantified in a large prospective US cohort, leaving uncertainty about whether histologic healing should be a treatment target.

## Solution

The TARGET-IBD registry was used to assess the association between histologic inflammation on index biopsy and loss of remission in corticosteroid-free UC patients in endoscopic remission, with multivariable Cox regression identifying histologic inflammation as an independent predictor of LOR.

## Impact

Establishing that histologic inflammation in endoscopic remission is associated with a two-fold increased risk of UC LOR provides real-world evidence supporting histologic remission as an additional treatment target beyond endoscopic remission, informing treat-to-target strategies for next-generation UC therapies.

### [Julie M. Crawford](/people/julie-crawford/)