---
title: >-
  International observational atopic dermatitis cohort to follow natural history
  and treatment course: TARGET-DERM AD study design and rationale.
description: >-
  Explore this publication on real-world evidence: International observational
  atopic dermatitis cohort to follow natural history and treatment course:…
date: '2020-01-01'
category: Publications
tags:
  - Bmj Open
  - Poster Presentation
  - R&D
  - Dermatology
  - Atopic Dermatitis (AD)
  - Pharma Partner
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/bmj-open/international-observational-atopic-dermatitis-cohort-to/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: international-observational-atopic-dermatitis-cohort-to
id: 5MJEWIl48dpeWOBgLnXZnz
contentType: article
---

## Challenge

Advanced AD therapy development required a prospective, longitudinal, multi-site real-world registry spanning all ages and both academic and community settings to generate the long-term comparative effectiveness, safety, and natural history data unobtainable from clinical trials.

## Solution

The TARGET-DERM AD study was designed as an international longitudinal observational cohort with broad inclusion criteria, collecting up to 8 years of medical records alongside patient-reported outcomes and optional biospecimens from US, Canadian, and European sites.

## Impact

Establishing the TARGET-DERM AD registry created the foundational real-world infrastructure for all subsequent AD natural history, treatment pattern, disparities, and PRO endpoint studies, directly enabling partnerships with AbbVie, Amgen, LEO Pharma, and other sponsors developing next-generation AD therapies.

### [Laura Dalfonso](/people/laura-dalfonso/)

![Laura Dalfonso, MBA — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/1EHQvEOTdVN9mIxegyhbip/0abef5a018b51d2ebbf1ea54555fe26b/laura-dalfonso.jpg)

### [Julie M. Crawford](/people/julie-crawford/)