---
title: >-
  Management of Hepatocellular Carcinoma (HCC) in a Real Life Multinational,
  Longitudinal, Observational Study (TARGET-HCC).
description: >-
  Explore this publication on real-world evidence: Management of Hepatocellular
  Carcinoma (HCC) in a Real Life Multinational, Longitudinal, Observational
  Study…
date: '2019-01-01'
category: Publications
tags:
  - EASL
  - Poster Presentation
  - R&D
  - Care
  - Hepatology
  - HCC
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/easl/management-of-hepatocellular-carcinoma-hcc-in-a-real-life/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: management-of-hepatocellular-carcinoma-hcc-in-a-real-life
id: 5CW8pC2kTKTE2gOj2rGs0s
contentType: article
---

## Challenge

Novel systemic therapies—including TKIs and immune checkpoint inhibitors—were expanding HCC treatment options, but real-world data on how treatment was actually sequenced by BCLC stage in an international multi-site registry were lacking, creating uncertainty about guideline adherence and practice variation.

## Solution

The TARGET-HCC cohort was analyzed to describe treatment receipt within 6 months of diagnosis by BCLC stage across 1,027 enrolled patients, characterizing locoregional and systemic therapy utilization patterns and identifying where real-world practice diverged from AASLD staging guidelines.

## Impact

Documenting that locoregional therapy use in advanced-stage HCC exceeded guideline recommendations identifies practice variation relevant to trial site selection and real-world effectiveness study design, and establishes the TARGET-HCC population profile for sponsors developing novel systemic therapies.