---
title: Non-invasive tests as a prediction tool to assess MASH resolution score.
description: >-
  Explore this publication on real-world evidence: Non-invasive tests as a
  prediction tool to assess MASH resolution score..
date: '2024-01-01'
category: Publications
tags:
  - NASH-TAG Conference
  - Poster Presentation
  - R&D
  - Care
  - Hepatology
  - MASH/MASLD
  - Pharma Partner
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/nash-tag/non-invasive-tests-as-a-prediction-tool-to-assess-mash/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: non-invasive-tests-as-a-prediction-tool-to-assess-mash
id: 3UrXzbKrWNe6urAFSoz3sJ
contentType: article
---

## Challenge

Non-invasive tests are individually imperfect predictors of MASH resolution, and the potential for sequential NIT algorithms—combining multiple tests in a stepwise fashion—to reduce diagnostic indeterminates while maintaining accuracy had not been explored in a real-world biopsy-confirmed MASH cohort.

## Solution

Paired liver biopsy and NIT data from TARGET-NASH were used to evaluate twelve sequential two- and three-test NIT algorithms using FIB-4, NFS, APRI, and VCTE for predicting NAS-derived MASH resolution, comparing performance characteristics and indeterminate rates across combinations.

## Impact

Demonstrating that sequential NIT algorithms—particularly FIB-4 followed by NFS and VCTE—can substantially reduce indeterminate classifications while maintaining accuracy provides a practical framework for non-invasive MASH monitoring in clinical practice and drug development, supporting biopsy-sparing trial designs.

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)

### [Breda Munoz](/people/breda-munoz/)

![Breda Munoz, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/3H1T2mfvSNFj6w9tulnreq/a74ae05fe53e400f176d4e9c617b8fb8/breda-munoz.jpg)

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)