---
title: >-
  Outcomes of early vs. delayed advanced therapy among patients with moderate
  ulcerative colitis in the United States: TARGET-IBD.
description: >-
  Explore this publication on real-world evidence: Outcomes of early vs. delayed
  advanced therapy among patients with moderate ulcerative colitis in the
  United…
date: '2023-01-01'
category: Publications
tags:
  - AIBD Conference
  - Poster Presentation
  - R&D
  - Care
  - Gastroenterology
  - GI - Other
  - Pharma Partner
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/aibd-conference/outcomes-of-early-vs-delayed-advanced-therapy-among/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: outcomes-of-early-vs-delayed-advanced-therapy-among
id: 3KfQMmwLfiAoP7etqQ4ulF
contentType: article
---

## Challenge

Moderate UC is a frequently overlooked population—often grouped with severe disease—yet real-world evidence on whether early versus delayed advanced therapy initiation meaningfully affects endoscopic remission in this specific group was lacking, leaving a gap in treat-to-target guidance for this population.

## Solution

The TARGET-IBD registry was used to compare the probability of endoscopic remission between early (<2 years from diagnosis) and delayed (>2 years) advanced therapy initiators among patients with moderate UC, using multivariable Cox proportional hazard models.

## Impact

Demonstrating that early advanced therapy initiation more than doubles the likelihood of endoscopic remission in moderate UC provides the real-world treat-to-target evidence needed to justify earlier escalation in this overlooked population, directly supporting Bristol Myers Squibb's label strategy and prescriber messaging.

### [Derek Gazis](/people/derek-gazis/)

![Derek Gazis, MS — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/1e4BaL8aZ7BBWMVV2cF6ev/425b52e4014543560f321fe4edd37631/derek-gazis.jpg)

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)

### [Julie M. Crawford](/people/julie-crawford/)