---
title: >-
  Patient-Reported Indicators of Health and Symptoms in US Patients with Primary
  Biliary Cholangitis (PBC).
description: >-
  Explore this publication on real-world evidence: Patient-Reported Indicators
  of Health and Symptoms in US Patients with Primary Biliary Cholangitis (PBC)..
date: '2018-01-01'
category: Publications
tags:
  - AASLD
  - Poster Presentation
  - R&D
  - Care
  - Hepatology
  - PBC
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/aasld/patient-reported-indicators-of-health-and-symptoms-in-us/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: patient-reported-indicators-of-health-and-symptoms-in-us
id: 4GF9NFMNoJZl4rdy6O493K
contentType: article
---

## Challenge

The degree to which clinician-reported symptom assessments in PBC underestimate patient-experienced symptom burden—particularly for pruritus and fatigue—had not been quantified in a real-world US cohort, limiting understanding of the PRO-clinical record gap relevant to endpoint design.

## Solution

The TARGET-PBC cohort's patient-reported outcomes were compared to corresponding clinician documentation in medical records, characterizing concordance rates between PRO-reported and medically documented symptoms across pruritus and fatigue severity categories.

## Impact

Demonstrating systematic underestimation of symptom severity by clinicians relative to patient-reported experience provides the justification for using validated PRO instruments rather than medical record-based symptom documentation as primary endpoints in PBC trials.