---
title: >-
  Patient Reported Outcomes Among Pediatric Patients with Nonalcoholic Fatty
  Liver Disease: TARGET-NASH.
description: >-
  Explore this publication on real-world evidence: Patient Reported Outcomes
  Among Pediatric Patients with Nonalcoholic Fatty Liver Disease: TARGET-NASH..
date: '2019-01-01'
category: Publications
tags:
  - AASLD
  - Poster Presentation
  - R&D
  - Care
  - Hepatology
  - MASH/MASLD
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/aasld/patient-reported-outcomes-among-pediatric-patients-with/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: patient-reported-outcomes-among-pediatric-patients-with
id: tKGz2a3QMZoKM7DInzFJW
contentType: article
---

## Challenge

Pediatric NAFLD patients experience disease-specific psychological burdens—including fatigue, anxiety, and depression—but whether these patient-reported outcomes differed meaningfully by disease severity in a real-world pediatric cohort had not been studied.

## Solution

The TARGET-NASH pediatric cohort was analyzed using validated PROMIS instruments to compare self-reported fatigue, anxiety, and depression T-scores across NAFL and NASH/cirrhosis subgroups, with stratification by ALT level.

## Impact

Characterizing that children with more severe NAFLD report higher fatigue and depression scores provides the evidence base for including patient-reported outcomes as endpoints in pediatric NAFLD trials and supports regulators' expectation that therapies demonstrate benefit across clinically meaningful patient experience domains.