---
title: >-
  Primary biliary cholangitis (PBC)-autoimmune hepatitis (AIH) overlap syndrome:
  Characteristics and response to obeticholic acid (OCA) in TARGET-PBC, a
  diverse, large United States (US) real- world cohort.
description: >-
  Explore this publication on real-world evidence: Primary biliary cholangitis
  (PBC)-autoimmune hepatitis (AIH) overlap syndrome: Characteristics and
  response…
date: '2019-01-01'
category: Publications
tags:
  - Care
  - DDW
  - PBC
  - Health System Partner
  - Poster Presentation
  - R&D
  - Hepatology
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/care/primary-biliary-cholangitis-pbc-autoimmune-hepatitis-aih/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: primary-biliary-cholangitis-pbc-autoimmune-hepatitis-aih
id: 2ATgZCwZwlYo1sljgRXohZ
contentType: article
---

## Challenge

PBC-AIH overlap syndrome is clinically important and potentially undertreated due to limited awareness, but the prevalence, clinical profile, and response to OCA in overlap patients had not been characterized in a large, real-world prospective US cohort.

## Solution

The TARGET-PBC cohort was used to identify overlap syndrome patients based on clinical and serological criteria and compare their characteristics, fibrosis burden, and OCA response to non-overlap PBC patients using descriptive statistics and comparative testing.

## Impact

Characterizing that overlap syndrome affects approximately 14% of real-world PBC patients, is associated with more advanced fibrosis, and shows comparable OCA response provides the clinical profile needed to support inclusive trial design and label language for second-line PBC therapies.