---
title: >-
  Real-World Treatment Patterns Among US Adults with Enresectable Hepatocellular
  Carcinoma (HCC) Eligible For Locoregional Therapy (LRT).
description: >-
  Explore this publication on real-world evidence: Real-World Treatment Patterns
  Among US Adults with Enresectable Hepatocellular Carcinoma (HCC) Eligible For…
date: '2025-01-01'
category: Publications
tags:
  - Approval / Commercialization
  - ASCO GI
  - Care
  - HCC
  - Pharma Partner
  - Poster Presentation
  - Hepatology
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/approval-commercialization/real-world-treatment-patterns-among-us-adults-with/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: real-world-treatment-patterns-among-us-adults-with
id: 5qN3ulGepoe5AM9OlKBvhP
contentType: article
---

## Challenge

The treatment landscape for unresectable non-metastatic HCC (uHCC) eligible for locoregional therapy was evolving rapidly with new systemic options, but real-world data on contemporary treatment patterns, outcomes, and the actual role of systemic therapy in this population were absent from post-2020 practice.

## Solution

The TARGET-HCC registry was used to identify uHCC patients initiating first treatment between 2020 and 2023 and characterize index treatment selection, subsequent treatment patterns, radiological progression, and survival outcomes using time-to-event analyses.

## Impact

Establishing contemporary real-world treatment pattern benchmarks for uHCC eligible for locoregional therapy informs the design of post-authorization effectiveness studies and provides the natural history context needed for sponsors developing combination locoregional-systemic HCC regimens.

### [Kathleen Hurwitz](/people/kathleen-hurwitz/)

### [Kayla Hendrickson](/people/kayla-hendrickson/)

### [Leah Jackman](/people/leah-jackman/)

### [Laney Bowden](/people/laney-bowden/)