---
title: >-
  Regional, racial/ethnic, and socioeconomic disparities and treatment outcomes
  in patients with hepatocellular carcinoma (HCC) in the US.
description: >-
  Explore this publication on real-world evidence: Regional, racial/ethnic, and
  socioeconomic disparities and treatment outcomes in patients with
  hepatocellular…
date: '2019-01-01'
category: Publications
tags:
  - ASCO GI
  - Poster Presentation
  - R&D
  - Care
  - Hepatology
  - HCC
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/asco-gi/regional-racial-ethnic-and-socioeconomic-disparities-and/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: regional-racial-ethnic-and-socioeconomic-disparities-and
id: 2alpjuhcPVgQxTPi30SD8J
contentType: article
---

## Challenge

Administrative database studies of HCC disparities lacked clinical covariates, and single-center studies lacked generalizability, leaving a gap in real-world evidence on whether racial, ethnic, socioeconomic, and geographic disparities actually translate into differences in HCC treatment receipt and outcomes when clinical confounders are properly controlled.

## Solution

The TARGET-HCC cohort was analyzed using multivariable logistic regression and Cox proportional hazard models with random intercepts for site to assess the association of race, ethnicity, insurance status, and geographic region with early tumor detection, curative intent therapy receipt, and overall survival.

## Impact

Demonstrating that socioeconomic disparities in curative intent therapy receipt persist after clinical adjustment—while racial/ethnic disparities in this cohort did not reach significance—provides actionable, clinically adjusted equity evidence for sponsors designing trials with diverse enrollment requirements and health equity commitments.