---
title: >-
  The impact of JAK inhibitor treatment on anxiety and depression outcomes and
  the role of eyebrow and eyelash hair regrowth in alopecia areata: TARGET-DERM.
description: >-
  Explore this publication on real-world evidence: The impact of JAK inhibitor
  treatment on anxiety and depression outcomes and the role of eyebrow and
  eyelash…
date: '2026-01-01'
category: Publications
tags:
  - Poster Presentation
  - R&D
  - Care
  - Dermatology
  - Alopecia Areata (AA)
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/poster-presentation/the-impact-of-jak-inhibitor-treatment-on-anxiety-and/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: the-impact-of-jak-inhibitor-treatment-on-anxiety-and
id: 2esJrS3zmVNveFO7WQrwII
contentType: article
---

## Challenge

The impact of JAK inhibitor treatment on psychiatric comorbidities—specifically anxiety and depression—and the role of eyebrow and eyelash regrowth on patient-reported outcomes in AA had not been characterized in a real-world longitudinal US/Canadian cohort, limiting understanding of the full patient benefit profile of JAK inhibitor therapy.

## Solution

The TARGET-DERM AA registry was analyzed to assess longitudinal changes in PROMIS anxiety and depression scores and the correlation between eyebrow/eyelash regrowth and patient-reported outcomes among patients receiving JAK inhibitor treatment.

## Impact

Demonstrating that JAK inhibitor treatment improves psychiatric outcomes and that eyebrow/eyelash regrowth meaningfully affects patient experience provides real-world evidence of the holistic benefit of JAK inhibitors in AA, supporting label claims and payer value arguments beyond scalp hair regrowth alone.