---
title: >-
  The Role of Disease Severity and Gender in Polypharmacy Among Patients with
  NAFLD Enrolled in TARGET-NASH.
description: >-
  Explore this publication on real-world evidence: The Role of Disease Severity
  and Gender in Polypharmacy Among Patients with NAFLD Enrolled in TARGET-NASH..
date: '2022-01-01'
category: Publications
tags:
  - AASLD The Liver Meeting
  - Poster Presentation
  - R&D
  - Care
  - Hepatology
  - MASH/MASLD
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/aasld-liver-meeting/the-role-of-disease-severity-and-gender-in-polypharmacy/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: the-role-of-disease-severity-and-gender-in-polypharmacy
id: 4uv2WIs8wnzVPWOTUZZCb5
contentType: article
---

## Challenge

The factors driving polypharmacy in NAFLD patients—particularly the interaction between disease severity, sex, and medication burden—had not been characterized at scale in a real-world population, creating a gap in the safety surveillance and drug development planning context for NAFLD therapeutics.

## Solution

The TARGET-NASH registry was analyzed to describe medication use patterns by disease severity and sex, characterizing polypharmacy prevalence, mechanism-of-action categories, and the predictors of medication burden using descriptive statistics and comparative testing.

## Impact

Characterizing that polypharmacy burden increases sharply with NAFLD severity—and that women with cirrhosis are particularly affected—provides drug developers with actionable concomitant medication context for NAFLD trial design and safety monitoring.

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)

### [Breda Munoz](/people/breda-munoz/)

![Breda Munoz, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/3H1T2mfvSNFj6w9tulnreq/a74ae05fe53e400f176d4e9c617b8fb8/breda-munoz.jpg)