---
title: >-
  The role of itch resolution and skin clearance in patient-reported atopic
  dermatitis severity and quality of life: Real-world Insights from TARGET-DERM
  AD.
description: >-
  Explore this publication on real-world evidence: The role of itch resolution
  and skin clearance in patient-reported atopic dermatitis severity and quality
  of…
date: '2023-01-01'
category: Publications
tags:
  - British Journal of Dermatology
  - Poster Presentation
  - Approval / Commercialization
  - Care
  - Dermatology
  - Atopic Dermatitis (AD)
  - Pharma Partner
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/british-journal-dermatology/the-role-of-itch-resolution-and-skin-clearance-in-patient/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: the-role-of-itch-resolution-and-skin-clearance-in-patient
id: 15YDPiRK5sF9pVj1jYMZ6j
contentType: article
---

## Challenge

Clinical trials in AD frequently use itch and skin clearance as separate endpoints, but whether achieving itch resolution and skin clearance have independent or additive effects on patient-reported outcomes in real-world practice—and which matters more to patients—had not been established in a large observational cohort.

## Solution

The TARGET-DERM AD registry was used to analyze the relationship between itch severity (NRS-itch) and skin clearance (vIGA-AD) and their independent and combined associations with POEM, DLQI, and other PROs, establishing the relative contribution of each treatment target to overall patient burden.

## Impact

Demonstrating that itch resolution and skin clearance each independently and additively drive PRO improvement provides the real-world clinical meaningfulness evidence needed to justify dual-target endpoints in AD trials and supports payer arguments that complete treatment responses deliver greater patient value than partial responses.

### [Keith D. Knapp](/people/keith-knapp/)

### [Breda Munoz](/people/breda-munoz/)

![Breda Munoz, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/3H1T2mfvSNFj6w9tulnreq/a74ae05fe53e400f176d4e9c617b8fb8/breda-munoz.jpg)

### [Julie M. Crawford](/people/julie-crawford/)