---
title: >-
  Time to Disease Progression and All-Cause Mortality in Adult MASH Patients in
  Real-World US Cohort.
description: >-
  Explore this publication on real-world evidence: Time to Disease Progression
  and All-Cause Mortality in Adult MASH Patients in Real-World US Cohort..
date: '2024-01-01'
category: Publications
tags:
  - AASLD The Liver Meeting
  - Poster Presentation
  - Approval / Commercialization
  - Care
  - Hepatology
  - MASH/MASLD
  - Pharma Partner
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/aasld-liver-meeting/time-to-disease-progression-and-all-cause-mortality-in/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: time-to-disease-progression-and-all-cause-mortality-in
id: 6a1xFRKAAgRyB0OG6LLKvI
contentType: article
---

## Challenge

Drug developers and payers needed real-world data on disease progression timelines and mortality risk across MASH severity strata—without cirrhosis, with compensated cirrhosis, and with decompensated cirrhosis—to model the value of intervention and design adequately powered outcome trials.

## Solution

The TARGET-NASH cohort was used to conduct time-to-event analyses of MASH progression to compensated cirrhosis, first decompensation event, and all-cause mortality across the three disease subgroups, generating cumulative incidence estimates and hazard ratios for each transition.

## Impact

Providing real-world progression rate and mortality benchmarks across MASH severity strata enables sponsors to build evidence-based natural history assumptions into economic models, power outcome trials appropriately, and demonstrate the value of disease-modifying therapy to payers and regulators.

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)