---
title: >-
  Treatment patterns among moderate-to-severe ulcerative colitis patients in
  TARGET-IBD.
description: >-
  Explore this publication on real-world evidence: Treatment patterns among
  moderate-to-severe ulcerative colitis patients in TARGET-IBD..
date: '2022-01-01'
category: Publications
tags:
  - AIBD Conference
  - Poster Presentation
  - Approval / Commercialization
  - Care
  - Gastroenterology
  - GI - Other
  - Pharma Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/aibd-conference/treatment-patterns-among-moderate-to-severe-ulcerative/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: treatment-patterns-among-moderate-to-severe-ulcerative
id: 4yy5oMvvTi9YH8EkFzPUyi
contentType: article
---

## Challenge

The treatment paradigm for moderate-to-severe UC was expanding rapidly with new biologics and JAK inhibitors, but real-world data characterizing treatment modification patterns—switching, dose escalation, augmentation—across advanced and conventional therapies had not been quantified in a large prospective US cohort.

## Solution

The TARGET-IBD registry was used to estimate the risk of treatment modification among moderate-to-severe UC patients initiating advanced or conventional therapies, using Fine-Gray sub-distribution hazard regression with funding from Bristol Myers Squibb.

## Impact

Demonstrating that patients initiating advanced therapies are less likely to require treatment modification than those on conventional therapies provides real-world comparative effectiveness evidence for the durability of biologics and JAK inhibitors in UC, supporting BMS's commercial and prescriber education strategy.

### [Julie M. Crawford](/people/julie-crawford/)

### [Breda Munoz](/people/breda-munoz/)

![Breda Munoz, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/3H1T2mfvSNFj6w9tulnreq/a74ae05fe53e400f176d4e9c617b8fb8/breda-munoz.jpg)

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)