---
title: >-
  Type 2 diabetes increases the risk of progression to metabolic
  dysfunction-associated steatohepatitis-related cirrhosis in a real world
  setting.
description: >-
  Explore this publication on real-world evidence: Type 2 diabetes increases the
  risk of progression to metabolic dysfunction-associated
  steatohepatitis-related…
date: '2024-01-01'
category: Publications
tags:
  - EASL Congress
  - Poster Presentation
  - Approval / Commercialization
  - Care
  - Hepatology
  - MASH/MASLD
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/easl-congress/type-2-diabetes-increases-the-risk-of-progression-to/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: type-2-diabetes-increases-the-risk-of-progression-to
id: 4D1QYjXvh7LRDzrdyzf5hI
contentType: article
---

## Challenge

Despite T2D being prevalent in MASLD and associated with worse outcomes, the size of the independent contribution of T2D to the risk of developing MASH-related cirrhosis—separate from baseline fibrosis severity—had not been quantified in a prospective real-world cohort with longitudinal follow-up.

## Solution

The TARGET-NASH endocrinology-hepatology collaboration used data from MASLD patients managed at both hepatology and endocrinology practices to model cirrhosis progression risk by T2D status, controlling for FIB-4 risk category, with results consistent across low and high baseline fibrosis subgroups.

## Impact

Demonstrating a consistent, approximately twofold increase in cirrhosis progression risk associated with T2D across fibrosis subgroups provides a strong real-world foundation for T2D-based enrichment in MASH trials and reinforces the clinical case for early intervention in MASLD patients with diabetes.

### [Heather L. Morris](/people/heather-morris/)

![Heather Morris, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/16PnQ817q7tv964vhcUD5f/ce6797c32df11f022ef12ecbb9ffea49/heather-morris.jpg)

### [Derek Gazis](/people/derek-gazis/)

![Derek Gazis, MS — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/1e4BaL8aZ7BBWMVV2cF6ev/425b52e4014543560f321fe4edd37631/derek-gazis.jpg)

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)