---
title: >-
  Use of Advanced Systemic Therapy in Patients with Moderate to Severe Atopic
  Dermatitis in the TARGET-DERM Registry.
description: >-
  Explore this publication on real-world evidence: Use of Advanced Systemic
  Therapy in Patients with Moderate to Severe Atopic Dermatitis in the
  TARGET-DERM…
date: '2022-01-01'
category: Publications
tags:
  - Care
  - Current Medical Research Opinion
  - Atopic Dermatitis (AD)
  - Health System Partner
  - Pharma Partner
  - Poster Presentation
  - R&D
  - Dermatology
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/care/use-of-advanced--2022-current-medical-research-opinion/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: use-of-advanced--2022-current-medical-research-opinion
id: 5d3Pv9X320WK0snXjKaQYp
contentType: article
---

## Challenge

Real-world data on the characteristics of adult patients with moderate-to-severe AD who had not initiated advanced systemic therapy—despite being clinically eligible—were absent, preventing a precise understanding of the treatment access and prescriber behavior barriers in US routine care.

## Solution

The TARGET-DERM AD registry was used to compare demographic characteristics, disease severity, prior treatment exposure, and clinical features between AST-naïve and AST-treated adults with moderate-to-severe AD, with logistic regression identifying independent predictors of remaining AST-naïve.

## Impact

Establishing that older age, male sex, and lower disease severity at enrollment independently predict remaining AST-naïve identifies specific patient subgroups most likely to be undertreated, informing prescriber education, trial enrollment design, and access program targeting for AD advanced therapies.

### [Keith D. Knapp](/people/keith-knapp/)

### [Breda Munoz](/people/breda-munoz/)

![Breda Munoz, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/3H1T2mfvSNFj6w9tulnreq/a74ae05fe53e400f176d4e9c617b8fb8/breda-munoz.jpg)

### [Julie M. Crawford](/people/julie-crawford/)