---
title: >-
  Use of sodium-glucose transport protein 2 inhibitors and dipeptidyl peptidase
  4 inhibitors in patients with MASLD in a real-world setting is associated with
  lower all-cause mortality.
description: >-
  Explore this publication on real-world evidence: Use of sodium-glucose
  transport protein 2 inhibitors and dipeptidyl peptidase 4 inhibitors in
  patients with…
date: '2024-01-01'
category: Publications
tags:
  - ACG
  - Poster Presentation
  - Approval / Commercialization
  - Care
  - Hepatology
  - MASH/MASLD
  - Health System Partner
canonical_url: >-
  https://www.pedestalhealth.com/resources/publications/acg/use-of-sodium-glucose-transport-protein-2-inhibitors-and/
source: Pedestal Health
license: © 2026 Pedestal Health. All rights reserved.
slug: use-of-sodium-glucose-transport-protein-2-inhibitors-and
id: anyv35KGdy1Qv9oBfPdGu
contentType: article
---

## Challenge

While GLP-1 RAs had attracted the most attention in MASLD, SGLT2 inhibitors and DPP4 inhibitors—also widely used in the T2D population—had received less study in terms of their real-world association with liver-relevant outcomes, leaving a gap in the comparative effectiveness evidence for metabolic-class drugs in MASLD.

## Solution

The TARGET-NASH cohort was used to identify MASLD patients using SGLT2 or DPP4 inhibitors for ≥1 year and compare their all-cause mortality to non-users, with multivariable Cox models adjusting for baseline characteristics.

## Impact

Demonstrating lower all-cause mortality associated with SGLT2 and DPP4 inhibitor use in real-world MASLD patients provides comparative effectiveness evidence relevant to the expanding landscape of metabolic drug development for MASH and supports the regulatory context for these agents' use in liver disease.

### [Breda Munoz](/people/breda-munoz/)

![Breda Munoz, PhD — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/3H1T2mfvSNFj6w9tulnreq/a74ae05fe53e400f176d4e9c617b8fb8/breda-munoz.jpg)

### [Andrea R. Mospan](/people/andrea-mospan/)

![Andrea R. Mospan, PhD, RAC — Profile Photo](https://images.ctfassets.net/h4s3ip99qawo/4w6bkwPHPqrXKYs4tHZPkK/1d21763b54ecc3466764986693b7072f/andrea-mospan.jpg)