Full-Spectrum Evidence

Observational. Interventional. Everything in between.

Powered by an engaged network of health systems and investigators

Delivered at the pace of life sciences innovation

Full-Spectrum Evidence

Observational. Interventional. Everything in between.

Life sciences innovation is breaking evidence generation.

More molecules are entering trials, more approvals have confirmatory evidence needs, and the system can't keep up.

The Question

The Decision

The Evidence Gap

Fixing it starts with an engaged network of health systems and their patients.

The pieces already exist, but need a better way of working together.

Health systems that share clinical data.

Academic and community sites, connecting records into one longitudinal view.

Patients who choose to take part.

They join the research and tell us what the chart can't.

Investigators who turn research into care.

Ready to run prospective studies and trials without starting from scratch.

Clinicians and scientists who know each disease.

Beginning in hepatology, dermatology, and gastroenterology.

Working together, we power full-spectrum evidence generation.

Our team partners with you to generate the right combination of data and studies, for a single research question or across an entire research program.

Real-world data and analytic services

Our clinicians, epidemiologists, and scientists design and conduct the study with you using our longitudinal, analysis-ready data.

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Prospective data collection

Seamlessly activate patients within the network to collect new information not captured in routine care.

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Full-service clinical trials

Interventional trials run end to end, with investigators who already treat your patients.

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So we can solve the problems health systems and life sciences have worked on for decades.

The right treatment, for the right patient, at the right time.

Older female researcher in white lab coat examining specimen through microscope in clinical research laboratory setting.

Life sciences

Evidence that carries forward from early development through approval and real-world use.

  • Clinical development

    Natural history, feasibility, protocol design and external control arms

  • Regulatory

    Post-authorization safety studies and longitudinal evidence for submissions

  • HEOR & market access

    Comparative effectiveness and market access evidence

  • Medical affairs

    Real-world treatment patterns and publication strategy

For Life Sciences →
Aerial view of two clinicians in white coats reviewing data on a tablet and notes while colleagues walk briskly through a hospital hallway.

Health systems

Research partnerships across academic and community settings.

  • Act on curated data from your own system

    Clinician-defined variables, linked to your own patients, under your governance

  • Learn at network scale

    Study your own cohort alone or alongside the network, and publish from either

  • Lead prospective and interventional studies

    Sponsored studies that fund your research program

For Health Systems →

To do this work, we assembled the team that shaped evidence generation as we know it.

Now we're writing the next chapter. Join us.

About us →Join our team →

130+

publications and congress presentations across hepatology, dermatology and gastroenterology

30+

life sciences organizations have trusted us to generate evidence

Portrait of Amy Abernethy, MD, PhD

Amy Abernethy, MD, PhD

Co-CEO

Cofounder of Highlander Health and former principal deputy commissioner of the FDA. A hematologist/oncologist and palliative medicine physician with 500+ publications, she has led change at Flatiron Health, Duke University and Verily.

Portrait of Brad Hirsch, MD

Brad Hirsch, MD

Co-CEO

Cofounder of Highlander Health and an oncologist, trialist, entrepreneur and product leader. He founded SignalPath, a clinical research technology company acquired by Verily, where he went on to lead product.

Portrait of Michael W. Fried, MD, FAASLD

Michael W. Fried, MD, FAASLD

Co-Founder & Chief Clinical Officer

Professor of Medicine at UNC Chapel Hill and past president of the American Association for the Study of Liver Diseases, with 30 years in clinical research and 200+ publications in liver disease.

Macro photograph of translucent oil bubbles on a vibrant orange and red gradient background, evoking scientific and biological imagery.

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