Race and ethnicity sub-groups of alopecia areata patients have differing clinical characteristics: TARGET-DERM AA.

Challenge

While AA is known to affect diverse populations, real-world data characterizing differences in disease severity, hair loss pattern, and eyebrow/eyelash involvement across racial and ethnic subgroups in a large North American registry were absent, limiting equity-conscious trial design and label generalizability.

Solution

The TARGET-DERM AA registry was analyzed to compare SALT scores, CGI-AA, PGIS-AA, and eyebrow/eyelash involvement across Non-Hispanic White, Hispanic, Non-Hispanic Black, and Non-Hispanic Asian AA patients in a cross-sectional analysis at enrollment.

Impact

Establishing that Non-Hispanic Asian patients have the highest rates of severe AA and NH-Hispanic patients the lowest provides the demographic stratification data needed to design representative AA trials and interpret subgroup analyses in regulatory submissions.