Time to Diagnosis Among Patients with Eosinophilic Esophagitis in the United States.

Challenge

EoE diagnosis is frequently delayed due to symptom overlap with other conditions, but the real-world magnitude of diagnostic delays—and which symptom presentations are associated with the longest journeys to diagnosis—had not been characterized in a large US EoE registry with prospective data.

Solution

The TARGET-EGIDs registry was used to describe the time from first EoE-related symptom or complication to confirmed diagnosis across 915 newly diagnosed EoE patients, stratified by symptom type and prior GERD diagnosis, with Bristol Myers Squibb as a funding partner.

Impact

Documenting that patients wait an average of 1–5 years from symptom onset to EoE diagnosis—with the longest delays in GERD-misdiagnosed patients—creates the evidence base for early diagnosis advocacy and supports the regulatory and commercial case for novel EoE therapies by demonstrating the unmet need of delayed intervention.