ISPE 2026 · Milan · Booth 300

Bring your evidence questions to Booth 300

More endpoints, smaller populations, faster timelines, and evidence obligations that outlast approval.

We're building a continuous system for evidence generation to meet them, one that serves clinical, regulatory, and strategic decisions across the full lifecycle of care.

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Presentations from Headwater Science at ISPE 2026

Our partners at Headwater Science are presenting new research on real-world methods and designs throughout the conference.

Poster · C-439

Wed 2 Sep · 12:00–1:30 PM CEST

Estimating recurrent complication burden under time-varying risk: a comparison of Poisson regression and the partitioned count estimator

Yasmmyn Salinas · with Teresa Bufford, Derek Gazis, Julie Crawford, Kathleen Hurwitz, Alan Brookhart

This analysis draws on Pedestal Health's IBD cohort: 1,022 adults with Crohn's disease followed across anti-TNFα and alternative advanced therapies.

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Built on Pedestal Health data. This analysis draws on Pedestal Health’s IBD cohort: 1,022 adults with Crohn’s disease followed across anti-TNFα and alternative advanced therapies.

The cohorts referenced here are managed under longstanding research protocols established by Pedestal Health (formerly Target RWE) and our academic partners. Protocol names including TARGET-IBD appear in published literature and are referenced where relevant for scientific accuracy.

Podium · 2A-02

Mon 31 Aug · 3:45–4:00 PM CEST

When can we ignore informative censoring?

Nuvan Rathnayaka · with Alan Brookhart, Kathleen Hurwitz

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Spotlight Poster · B-284

Tue 1 Sep · 11:30 AM–1:00 PM CEST

Effect of varying pre-interruption periods on interrupted time series estimates and interpretation: a simulation study

Rachel Faller · with Nuvan Rathnayaka

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Poster · C-123

Wed 2 Sep · 12:00–1:30 PM CEST

Regional and variant-era variation in treatment patterns and remdesivir use among immunocompromised patients hospitalized with COVID-19: an analysis of polypharmacy using UpSet plots

Kayla Hendrickson · with Nuvan Rathnayaka, Mark Berry (Gilead), Carrie Nielson (Gilead), Alan Brookhart, Kathleen Hurwitz

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Poster · C-350

Wed 2 Sep · 12:00–1:30 PM CEST

Standard error estimation for transported effects in sequential nested trial emulations using M-estimation

Catie Wiener · with Chase Latour, Jeanny Wang, Paul Zivich, Alan Brookhart

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Workshop · SW-2G

Mon 31 Aug · 5:15–6:45 PM CEST

Fake world data, real world problems: simulations for the pharmacoepidemiologist

Catie Wiener, Alexander Breskin, Amarnath Marthi · with Chase Latour

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Pedestal Health works with Headwater Science at every stage of evidence generation, drawing on its methods, technology, and causal inference expertise. That partnership runs through comparative effectiveness studies requiring dynamic treatment design, regulatory-grade external control work, methodological consultation on submission packages, and the bias-protection frameworks that consequential evidence increasingly requires.

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